Here is our quick file setup checklist for Fusion360:
File is exported as a DXF;
All holes and cutouts are at least 50% material thickness;
File is built at a 1:1 scale, preferably in inch units;
All objects are on the same layer;
All stray points, duplicate lines, empty objects and text areas have been removed;
No shapes have open contours;
All shapes have been united, combined or merged;
All text has been converted to outlines or paths;
Cut-out text (reversed text) has bridges or has been stencilized.
For more information on file setup and designing laser cut parts in Fusion360, check out our Fusion360 blog posts and the video tutorial below.